The autoplay option in computer is extremely harmful in case of using infected pen drives. It lets the Virus enter before you can take action. Your Anti Virus may detect it, but not always. Here is one simple solution (For Windows7 but applicable to other older versions of Windows as well) to keep your computer safe from Virus entering through USB Drive:

>Go to Start

>Control panel

>Choose System and Security

>Double Click Administrative tools

>Look for Services

>Find  Shell Hardware Detection: It provides notifications for AutoPlay hardware events

>Right Click and select Properties

>From the drop down button of Startup type choose Disable

>Ok

I hope that keeps your PC safe. I’ll also talk about malware removal from computer and Pen Drive in my next post.